Bone Disorders Essay Example | Topics and Well Written Essays - 1250 words

Bone Disorders - Essay Example Bone problems are of different kinds. They may include osteoporosis caused by low density of bone and which makes bones weak and susceptible to breakage, osteogenesis imperfect which increases the brittleness of bones, and Paget’s bones disease which makes bones weaker. In addition to these bone disorders, bones may also develop a range of infections and cancers. There can be many reasons for the development of bone disorders. Some major causes of bone disorders include genetic factors, poor nutrition, and poor rate of rebuilding and growth of bones. The most important modulators of the process by which bones form are hormones. Optimal development and maintenance of bones depends upon parathyroid hormone, estrogen, and testosterone. Of these, the most direct impact on the cells of bone is made by estrogen which interacts with specific receptors or proteins on the surface of osteoclasts and osteoblasts (Zallone, 2006). Bones maintain their strength and integrity through a process of continuous renewal known as remodeling. Accelerated bone remodeling may cause a range of bone disorders that include but are not limited to familial expansile osteolysis (FEO), juvenile Pagets disease (JPD), Pagets disease of bone (PDB), early-onset Pagets disease of bone (EOPDB), and expansile skeletal hyperphosphatasia (ESH) (Beyens and Van Hul, 2007). Many stud ies have concluded that the main cells responsible for causing disease in these bone disorders are bone-resorbing osteoclasts. Connective tissues are unlike the parenchymal organs in that their form and function reflects the extracellular matrices of the matter they are made up of. These different compositions of matrices lend unique appearance and mechanical properties to cartilage, bone, and dense fibrous connective tissue (Teitelbaum and Bullough, 1979). Dense fibrous connective tissue is made up of collagen in the form of well-oriented collagen bundles whose main